The Challenge

The Challenge

Adaptation of the CAR T therapy to solid tumors

First line product: CAR T against HER2-positive cancers

Examples of toxicities reported in patients with HER2 positive tumors include fatal pulmonary complications in a metastatic colon cancer patient, gastrointestinal hemorrhage in two patients with metastatic biliary tract and pancreatic cancer and cardiotoxicity in trastuzumab-treated breast cancer patients [Mol Ther. 2010;18(4):843–51, Protein Cell. 2018 Oct;9(10):838-847]